RT Journal Article SR Electronic T1 PET in Infancy Predicts Long-Term Outcome during Adolescence in Cryptogenic West Syndrome JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 1580 OP 1585 DO 10.3174/ajnr.A3899 VO 35 IS 8 A1 J. Natsume A1 N. Maeda A1 K. Itomi A1 H. Kidokoro A1 N. Ishihara A1 H. Takada A1 A. Okumura A1 T. Kubota A1 K. Miura A1 K. Aso A1 T. Morikawa A1 K. Kato A1 T. Negoro A1 K. Watanabe YR 2014 UL http://www.ajnr.org/content/35/8/1580.abstract AB BACKGROUND AND PURPOSE: Developmental and seizure outcomes in patients with cryptogenic West syndrome are variable. Our aim was to clarify the relationship between FDG-PET findings in infancy and long-term seizure and developmental outcome in cryptogenic West syndrome. MATERIALS AND METHODS: From 1991 to 1999, we prospectively performed FDG-PET from the onset of cryptogenic West syndrome in 27 patients. PET was performed at onset and at 10 months of age. In 2012, we evaluated the educational status, psychomotor development, and seizure outcome in 23 of the 27 patients (13–22 years of age). The correlation between PET findings and outcome was evaluated. RESULTS: At onset, PET showed hypometabolism in 13 patients (57%). The second PET after the initial treatment revealed cortical hypometabolism in 7 patients (30%). While hypometabolism at onset disappeared on the second PET in 9 patients, it was newly revealed in 3 patients on the second PET. In 2012, seven patients had persistent or recurrent seizures. Eight patients had intellectual impairment. The first PET did not correlate with seizure or developmental outcome. Five of 7 patients (71%) with hypometabolism seen on the second PET had persistent or recurrent seizures, while 14 of 16 (88%) patients with normal findings on the second PET were free of seizures. Five of 7 patients (71%) showing hypometabolism on the second PET had intellectual impairment. Thirteen of 16 (81%) patients with normal findings on the second PET showed normal intelligence. A significant correlation was found between the second PET and long-term seizure (P = .01) or developmental outcome (P = .03). CONCLUSIONS: Cortical hypometabolism is not permanent; it changes with clinical symptoms. Hypometabolism after initial treatment predicts long-term seizures and poor developmental outcome. ACTHadrenocorticotropic hormoneDQdevelopmental quotientEEGelectroencephalographyIQintelligence quotient