TY - JOUR T1 - Relative Filling Time Delay Based on CT Perfusion Source Imaging: A Simple Method to Predict Outcome in Acute Ischemic Stroke JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1683 LP - 1687 DO - 10.3174/ajnr.A3931 VL - 35 IS - 9 AU - W. Cao AU - B.C.V. Campbell AU - Q. Dong AU - S.M. Davis AU - B. Yan Y1 - 2014/09/01 UR - http://www.ajnr.org/content/35/9/1683.abstract N2 - BACKGROUND AND PURPOSE: Collateral vessel status is strongly associated with clinical outcome in ischemic stroke but can be challenging to assess. The aim of this study was to develop a tomography perfusion source imaging–based assessment of collateral vessel status. MATERIALS AND METHODS: Consecutive patients with ischemic stroke who received intravenous thrombolysis or intra-arterial reperfusion therapy after CTP were retrospectively analyzed. In those with middle cerebral artery or internal carotid artery occlusion, CT perfusion source imaging was used to identify the relative filling time delay between the normal MCA Sylvian branches and those in the affected hemisphere. Receiver operating characteristic analysis and logistic regression were used to assess the association of the relative filling time delay with the 24-hour Alberta Stroke Program Early CT Score based on noncontrast CT and the 90-day modified Rankin Scale score. RESULTS: There were 217 patients treated in 2009–2011 who had CTP data, of whom 60 had MCA or ICA occlusion and 55 had 90-day mRS data. The intraclass correlation coefficient for relative filling time delay was 0.95. Relative filling time delay was correlated with 24-hour ASPECTS (Spearman ρ = −0.674; P < .001) and 90-day mRS score (ρ = 0.516, P < .01). Increased relative filling time delay was associated with poor radiologic outcome (ASPECTS, 0–7) (area under the curve = 0.79, P < .001) and poor functional outcome (mRS score, 3–6) (area under the curve = 0.77, P = .001). In multivariate logistic regression, the association of longer relative filling time delay with poor outcome remained significant, independent of age, sex, and baseline National Institutes of Health Stroke Scale score. CONCLUSIONS: Relative filling time delay is a useful independent predictor of clinical outcome after ischemic stroke. CTP-SICT perfusion source imagingrFTDrelative filling time delay ER -