TY - JOUR T1 - Intracranial Aneurysmal Pulsatility as a New Individual Criterion for Rupture Risk Evaluation: Biomechanical and Numeric Approach (IRRAs Project) JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1765 LP - 1771 DO - 10.3174/ajnr.A3949 VL - 35 IS - 9 AU - M. Sanchez AU - O. Ecker AU - D. Ambard AU - F. Jourdan AU - F. Nicoud AU - S. Mendez AU - J.-P. Lejeune AU - L. Thines AU - H. Dufour AU - H. Brunel AU - P. Machi AU - K. Lobotesis AU - A. Bonafe AU - V. Costalat Y1 - 2014/09/01 UR - http://www.ajnr.org/content/35/9/1765.abstract N2 - BACKGROUND AND PURPOSE: The present study follows an experimental work based on the characterization of the biomechanical behavior of the aneurysmal wall and a numerical study where a significant difference in term of volume variation between ruptured and unruptured aneurysm was observed in a specific case. Our study was designed to highlight by means of numeric simulations the correlation between aneurysm sac pulsatility and the risk of rupture through the mechanical properties of the wall. MATERIALS AND METHODS: In accordance with previous work suggesting a correlation between the risk of rupture and the material properties of cerebral aneurysms, 12 fluid-structure interaction computations were performed on 12 “patient-specific” cases, corresponding to typical shapes and locations of cerebral aneurysms. The variations of the aneurysmal volume during the cardiac cycle (ΔV) are compared by using wall material characteristics of either degraded or nondegraded tissues. RESULTS: Aneurysms were located on 6 different arteries: middle cerebral artery (4), anterior cerebral artery (3), internal carotid artery (1), vertebral artery (1), ophthalmic artery (1), and basilar artery (1). Aneurysms presented different shapes (uniform or multilobulated) and diastolic volumes (from 18 to 392 mm3). The pulsatility (ΔV/V) was significantly larger for a soft aneurysmal material (average of 26%) than for a stiff material (average of 4%). The difference between ΔV, for each condition, was statistically significant: P = .005. CONCLUSIONS: The difference in aneurysmal pulsatility as highlighted in this work might be a relevant patient-specific predictor of aneurysm risk of rupture. FSIfluid-structure interaction ER -