RT Journal Article
SR Electronic
T1 The Success of Flow Diversion in Large and Giant Sidewall Aneurysms May Depend on the Size of the Defect in the Parent Artery
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2119
OP 2124
DO 10.3174/ajnr.A4010
VO 35
IS 11
A1 J.C. Gentric
A1 T.E. Darsaut
A1 A. Makoyeva
A1 I. Salazkin
A1 J. Raymond
YR 2014
UL http://www.ajnr.org/content/35/11/2119.abstract
AB BACKGROUND AND PURPOSE: Flow diverters are designed to occlude aneurysms while preserving flow to jailed arterial branches. We postulated that treatment success depended on the size of the aneurysm ostium or defect in the parent artery. MATERIALS AND METHODS: Flow diverter expansion and deformation were studied in silicone tubes with wall apertures of various sizes. Large and giant canine sidewall aneurysms, featuring a branch located immediately opposite the aneurysm, and a smaller 6- to 8-mm (group A, n = 6) or a larger 10- to 16-mm (group B, n = 6) ostium were created to study the effects of ostium size on aneurysm or branch occlusion by flow diverters. Angiographic results after deployment and at 3 months were scored by using an ordinal scale. The amount of neointima formation on the segment of the device overlying the aneurysm or the branch ostia was determined by specimen photography. RESULTS: The fusiform deformation of flow diverters was maximal with larger defects in silicone tubes. At 3 months, group B aneurysms showed worse angiographic results than group A aneurysms, with larger residual aneurysm volumes (P = .002). Neointimal coverage of the aneurysm ostia was more complete in group A compared with group B (P = .002). CONCLUSIONS: The effects of flow diversion may vary with the size of the aneurysm ostium. FDflow diverterFSSfree segment of the stent