PT  - JOURNAL ARTICLE
AU  - Darsaut, T.E.
AU  - Gentric, J.-C.
AU  - McDougall, C.M.
AU  - Gevry, G.
AU  - Roy, D.
AU  - Weill, A.
AU  - Raymond, J.
TI  - Uncertainty and Agreement Regarding the Role of Flow Diversion in the Management of Difficult Aneurysms
AID  - 10.3174/ajnr.A4201
DP  - 2015 May 01
TA  - American Journal of Neuroradiology
PG  - 930--936
VI  - 36
IP  - 5
4099  - http://www.ajnr.org/content/36/5/930.short
4100  - http://www.ajnr.org/content/36/5/930.full
SO  - Am. J. Neuroradiol.2015 May 01; 36
AB  - BACKGROUND AND PURPOSE: The role of flow diversion in the management of aneurysms remains unknown. We sought to evaluate the community agreement regarding indications for flow diversion. MATERIALS AND METHODS: A portfolio of 35 difficult aneurysm cases was sent to 40 clinicians with varying backgrounds and experience. Responders were asked whether they considered flow diversion a treatment option, whether other options were possible, whether recruitment in a randomized trial would be considered, and to select their final choice. Agreement was studied by using κ statistics. RESULTS: Decisions for flow diversion were more frequent (n = 300, 39%) than decisions to coil (n = 163, 21.2%), to observe (n = 121, 15.7%), to occlude the parent vessel (n = 102, 13.2%), or to clip (n = 66, 8.6%). Sidewall aneurysm morphology was associated with flow diversion as the final choice (P = .001). Interjudge agreement was fair at best (κ <0.3) for all cases and all judges, despite high certainty levels (range, 7.2–8.9 ± 2.0 on a 0–10 scale). Agreement was no better within specialties or with more experience. All patients were judged to have other treatment options. Judges were willing to offer trial participation in 417 of 741 (56.3%) scenarios, more frequently when the aneurysm was sidewall (P = .001) or in the anterior circulation (P = .028). CONCLUSIONS: Individuals did not agree regarding the indications for flow diversion. There is sufficient uncertainty to justify trials designed to protect patients from the potential risks of premature adoption of an innovation. BSTbest standard treatmentCLconfidence levelFDflow diversionFIATFlow diversion In Aneurysm TreatmentRCTrandomized controlled trial