PT  - JOURNAL ARTICLE
AU  - C.P. Wanamaker
AU  - S. Fakhran
AU  - L.M. Alhilali
TI  - Qualitative and Quantitative Analysis of MR Imaging Findings in Patients with Middle Cerebral Artery Stroke Implanted with Mesenchymal Stem Cells
AID  - 10.3174/ajnr.A4232
DP  - 2015 Jun 01
TA  - American Journal of Neuroradiology
PG  - 1063--1068
VI  - 36
IP  - 6
4099  - http://www.ajnr.org/content/36/6/1063.short
4100  - http://www.ajnr.org/content/36/6/1063.full
SO  - Am. J. Neuroradiol.2015 Jun 01; 36
AB  - BACKGROUND AND PURPOSE: Mesenchymal stem cells have potential as a regenerative therapy in ischemic stroke. We sought to determine MR imaging findings after mesenchymal stem cell implantation in chronic middle cerebral artery infarcts and to compare brain volume changes in patients with mesenchymal stem cells with those in age-matched healthy controls and controls with chronic stable MCA infarcts.MATERIALS AND METHODS: We retrospectively identified 5 patients receiving surgical mesenchymal stem cell implantation to an MCA infarct from January 1, 2005, to July 1, 2013, with MR imaging immediately and 1 year postimplantation. Images at both time points were evaluated for any postimplantation complications. Structural image evaluation using normalization of atrophy software was used to determine volume changes between time points and compare them with those in healthy and age- and sex-matched controls with chronic, stable MCA infarcts by using Kruskal-Wallis and Mann-Whitney U tests.RESULTS: Susceptibility signal loss and enhancement at the implantation site were seen. No teratoma, tumor, or heterotopia was identified. Volumetric analysis showed a trend toward less overall volume loss after mesenchymal stem cell implantation (0.736; 95% CI, −4.15–5.62) compared with that in age- and sex-matched controls with chronic, stable MCA infarcts (−3.59; 95% CI, −12.3 to −5.21; P = .09), with a significantly greater growth-to-loss ratio in infarcted regions (1.30 and 0.78, respectively, P = .02). A trend toward correlation of growth-to-loss ratio with improvement in physical examination findings was seen (r = 0.856, P = .06).CONCLUSIONS: Postoperative changes consistent with stereotactic implantation were seen, but no teratoma, tumor, or heterotopia was identified. Initial findings suggest a trend toward less volume loss after mesenchymal stem cell implantation compared with that in age- and sex-matched controls with chronic, stable MCA infarcts, with a significantly greater growth-to-loss ratio in the infarcted tissue.%BVCpercentage brain volume changeGLRgrowth-to-loss ratioMCAI controlsage- and sex-matched controls with chronic, stable MCA infarctsMSCmesenchymal stem cellsSIENAstructural image evaluation using normalization of atrophySTsection thickness