PT - JOURNAL ARTICLE AU - A.K. Wakhloo AU - P. Lylyk AU - J. de Vries AU - C. Taschner AU - J. Lundquist AU - A. Biondi AU - M. Hartmann AU - I. Szikora AU - L. Pierot AU - N. Sakai AU - H. Imamura AU - N. Sourour AU - I. Rennie AU - M. Skalej AU - O. Beuing AU - A. Bonafé AU - F. Mery AU - F. Turjman AU - P. Brouwer AU - E. Boccardi AU - L. Valvassori AU - S. Derakhshani AU - M.W. Litzenberg AU - M.J. Gounis AU - for the Surpass Study Group TI - Surpass Flow Diverter in the Treatment of Intracranial Aneurysms: A Prospective Multicenter Study AID - 10.3174/ajnr.A4078 DP - 2015 Jan 01 TA - American Journal of Neuroradiology PG - 98--107 VI - 36 IP - 1 4099 - http://www.ajnr.org/content/36/1/98.short 4100 - http://www.ajnr.org/content/36/1/98.full SO - Am. J. Neuroradiol.2015 Jan 01; 36 AB - BACKGROUND AND PURPOSE: Incomplete occlusion and recanalization of large and wide-neck brain aneurysms treated by endovascular therapy remains a challenge. We present preliminary clinical and angiographic results of an experimentally optimized Surpass flow diverter for treatment of intracranial aneurysms in a prospective, multicenter, nonrandomized, single-arm study. MATERIALS AND METHODS: At 24 centers, 165 patients with 190 intracranial aneurysms of the anterior and posterior circulations were enrolled. The primary efficacy end point was the percentage of intracranial aneurysms with 100% occlusion on 6-month DSA. The primary safety end point was neurologic death and any stroke through a minimum follow-up of 6 months. RESULTS: Successful flow-diverter delivery was achieved in 161 patients with 186 aneurysms (98%); the mean number of devices used per aneurysm was 1.05. Clinical follow-up (median, 6 months) of 150 patients (93.2%), showed that the primary safety end point occurred in 18 subjects. Permanent neurologic morbidity and mortality were 6% and 2.7%, respectively. Morbidity occurred in 4% and 7.4% of patients treated for aneurysms of the anterior and posterior circulation, respectively. Neurologic death during follow-up was observed in 1.6% and 7.4% of patients with treated intracranial aneurysms of the anterior and posterior circulation, respectively. Ischemic stroke at ≤30 days, SAH at ≤7 days, and intraparenchymal hemorrhage at ≤7 days were encountered in 3.7%, 2.5%, and 2.5% of subjects, respectively. No disabling ischemic strokes at >30 days or SAH at >7 days occurred. New or worsening cranial nerve deficit was observed in 2.7%. Follow-up angiography available in 158 (86.8%) intracranial aneurysms showed 100% occlusion in 75%. CONCLUSIONS: Clinical outcomes of the Surpass flow diverter in the treatment of intracranial aneurysms show a safety profile that is comparable with that of stent-assisted coil embolization. Angiographic results showed a high rate of intracranial aneurysm occlusion. EVTendovascular treatmentFDflow diverterPUFSPipeline Embolization Device for Uncoilable or Failed Aneurysms