TY - JOUR T1 - Identifying Corticothalamic Network Epicenters in Patients with Idiopathic Generalized Epilepsy JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1494 LP - 1500 DO - 10.3174/ajnr.A4308 VL - 36 IS - 8 AU - G.-J. Ji AU - Z. Zhang AU - Q. Xu AU - Z. Wang AU - J. Wang AU - Q. Jiao AU - F. Yang AU - Q. Tan AU - G. Chen AU - Y.-F. Zang AU - W. Liao AU - G. Lu Y1 - 2015/08/01 UR - http://www.ajnr.org/content/36/8/1494.abstract N2 - BACKGROUND AND PURPOSE: Corticothalamic networks are considered core pathologic substrates for idiopathic generalized epilepsy; however, the predominant epileptogenic epicenters within these networks are still largely unknown. The current study aims to identify these epicenters by resting-state functional connectivity.MATERIALS AND METHODS: To identify epicenters within the corticothalamic networks in idiopathic generalized epilepsy, we retrospectively studied a large cohort of patients with this condition (n = 97) along with healthy controls (n = 123) by resting-state functional MR imaging. The thalamus was functionally divided into subregions corresponding to distinct cortical lobes for 5 parallel corticothalamic networks. The functional connectivity between each voxel in the cortical lobe and the corresponding thalamic subregion was calculated, and functional connectivity strength was used to evaluate the interconnectivity of voxels in the cortex and thalamus.RESULTS: The projection of 5 cortical lobes to the thalamus is consistent with previous histologic findings in humans. Compared with controls, patients with idiopathic generalized epilepsy showed increased functional connectivity strength in 4 corticothalamic networks: 1) the supplementary motor area, pulvinar, and ventral anterior nucleus in the prefrontal-thalamic network; 2) the premotor cortex and ventrolateral nucleus in motor/premotor-thalamic networks; 3) the visual cortex, posterior default mode regions, and pulvinar in parietal/occipital-thalamic networks; and 4) the middle temporal gyrus in the temporal-thalamic network.CONCLUSIONS: Several key nodes were distinguished in 4 corticothalamic networks. The identification of these epicenters refines the corticothalamic network theory and provides insight into the pathophysiology of idiopathic generalized epilepsy.FCSfunctional connectivity strengthGSWDgeneralized spike-wave dischargeIGEidiopathic generalized epilepsySMAsupplementary motor area ER -