RT Journal Article SR Electronic T1 Current Applications of MRI-Guided Laser Interstitial Thermal Therapy in the Treatment of Brain Neoplasms and Epilepsy: A Radiologic and Neurosurgical Overview JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 1998 OP 2006 DO 10.3174/ajnr.A4362 VO 36 IS 11 A1 R. Medvid A1 A. Ruiz A1 R.J. Komotar A1 J.R. Jagid A1 M.E. Ivan A1 R.M. Quencer A1 M.B. Desai YR 2015 UL http://www.ajnr.org/content/36/11/1998.abstract AB SUMMARY: Minimally invasive stereotactic tumor ablation is a viable option for the treatment of benign and malignant intracranial lesions. Although surgical excision constitutes first-line therapy for various brain pathologies, it can cause irreversible neurologic deficits. Additionally, many patients who may benefit from surgery do not qualify as surgical candidates due to multiple comorbidities. Recent advancements in laser interstitial thermal therapy, namely the ability to monitor ablation in real-time under MR imaging, have improved the safety and efficacy of the procedure. MRI-guided laser interstitial thermal therapy is currently used as a minimally invasive treatment for brain metastases, radiation necrosis, glioma, and epilepsy. This article will discuss the principles, suggested indications, complications, and imaging characteristics of MRI-guided laser interstitial thermal therapy as they pertain to the treatment of brain pathology.GBMglioblastoma multiformeLITTlaser interstitial thermal therapyMRgLITTMRI-guided laser interstitial thermal therapyMRTIMRI thermal imagingRNdelayed radiation necrosisSRSstereotactic radiosurgery