RT Journal Article SR Electronic T1 Comparison of the Diagnostic Accuracy of DSC- and Dynamic Contrast-Enhanced MRI in the Preoperative Grading of Astrocytomas JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 2017 OP 2022 DO 10.3174/ajnr.A4398 VO 36 IS 11 A1 T.B. Nguyen A1 G.O. Cron A1 K. Perdrizet A1 K. Bezzina A1 C.H. Torres A1 S. Chakraborty A1 J. Woulfe A1 G.H. Jansen A1 J. Sinclair A1 R.E. Thornhill A1 C. Foottit A1 B. Zanette A1 I.G. Cameron YR 2015 UL http://www.ajnr.org/content/36/11/2017.abstract AB BACKGROUND AND PURPOSE: Dynamic contrast-enhanced MR imaging parameters can be biased by poor measurement of the vascular input function. We have compared the diagnostic accuracy of dynamic contrast-enhanced MR imaging by using a phase-derived vascular input function and “bookend” T1 measurements with DSC MR imaging for preoperative grading of astrocytomas.MATERIALS AND METHODS: This prospective study included 48 patients with a new pathologic diagnosis of an astrocytoma. Preoperative MR imaging was performed at 3T, which included 2 injections of 5-mL gadobutrol for dynamic contrast-enhanced and DSC MR imaging. During dynamic contrast-enhanced MR imaging, both magnitude and phase images were acquired to estimate plasma volume obtained from phase-derived vascular input function (Vp_Φ) and volume transfer constant obtained from phase-derived vascular input function (Ktrans_Φ) as well as plasma volume obtained from magnitude-derived vascular input function (Vp_SI) and volume transfer constant obtained from magnitude-derived vascular input function (Ktrans_SI). From DSC MR imaging, corrected relative CBV was computed. Four ROIs were placed over the solid part of the tumor, and the highest value among the ROIs was recorded. A Mann-Whitney U test was used to test for difference between grades. Diagnostic accuracy was assessed by using receiver operating characteristic analysis.RESULTS: Vp_ Φ and Ktrans_Φ values were lower for grade II compared with grade III astrocytomas (P < .05). Vp_SI and Ktrans_SI were not significantly different between grade II and grade III astrocytomas (P = .08–0.15). Relative CBV and dynamic contrast-enhanced MR imaging parameters except for Ktrans_SI were lower for grade III compared with grade IV (P ≤ .05). In differentiating low- and high-grade astrocytomas, we found no statistically significant difference in diagnostic accuracy between relative CBV and dynamic contrast-enhanced MR imaging parameters.CONCLUSIONS: In the preoperative grading of astrocytomas, the diagnostic accuracy of dynamic contrast-enhanced MR imaging parameters is similar to that of relative CBV.DCEdynamic contrast-enhancedKtrans_Φvolume transfer constant obtained from phase-derived vascular input functionKtrans_SIvolume transfer constant obtained from magnitude-derived vascular input functionrCBVrelative CBVSIsignal intensityVIFvascular input functionVpplasma volumeVp_Φplasma volume obtained from phase-derived vascular input functionVp_SIplasma volume obtained from magnitude-derived vascular input function