RT Journal Article SR Electronic T1 Voxel-Based Morphometry and fMRI Revealed Differences in Brain Gray Matter in Breastfed and Milk Formula–Fed Children JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 713 OP 719 DO 10.3174/ajnr.A4593 VO 37 IS 4 A1 X. Ou A1 A. Andres A1 R.T. Pivik A1 M.A. Cleves A1 J.H. Snow A1 Z. Ding A1 T.M. Badger YR 2016 UL http://www.ajnr.org/content/37/4/713.abstract AB BACKGROUND AND PURPOSE: Infant diets may have significant impact on brain development in children. The aim of this study was to evaluate brain gray matter structure and function in 8-year-old children who were predominantly breastfed or fed cow's milk formula as infants.MATERIALS AND METHODS: Forty-two healthy children (breastfed: n = 22, 10 boys and 12 girls; cow's milk formula: n = 20, 10 boys and 10 girls) were studied by using structural MR imaging (3D T1-weighted imaging) and blood oxygen level–dependent fMRI (while performing tasks involving visual perception and language functions). They were also administered standardized tests evaluating intelligence (Reynolds Intellectual Assessment Scales) and language skills (Clinical Evaluation of Language Fundamentals).RESULTS: Total brain gray matter volume did not differ between the breastfed and cow's milk formula groups. However, breastfed children had significantly higher (P < .05, corrected) regional gray matter volume measured by voxel-based morphometry in the left inferior temporal lobe and left superior parietal lobe compared with cow's milk formula–fed children. Breastfed children showed significantly more brain activation in the right frontal and left/right temporal lobes on fMRI when processing the perception task and in the left temporal/occipital lobe when processing the visual language task than cow's milk formula–fed children. The imaging findings were associated with significantly better performance for breastfed than cow's milk formula–fed children on both tasks.CONCLUSIONS: Our findings indicated greater regional gray matter development and better regional gray matter function in breastfed than cow's milk formula–fed children at 8 years of age and suggested that infant diets may have long-term influences on brain development in children.BFbreastfedCELF-4Clinical Evaluation of Language Fundamentals, Fourth EditionIQintelligent quotientMFcow's milk formula-fedRIASReynolds Intellectual Assessment ScalesVBMvoxel-based morphometry