PT - JOURNAL ARTICLE AU - M. Azuma AU - T. Hirai AU - K. Yamada AU - S. Yamashita AU - Y. Ando AU - M. Tateishi AU - Y. Iryo AU - T. Yoneda AU - M. Kitajima AU - Y. Wang AU - Y. Yamashita TI - Lateral Asymmetry and Spatial Difference of Iron Deposition in the Substantia Nigra of Patients with Parkinson Disease Measured with Quantitative Susceptibility Mapping AID - 10.3174/ajnr.A4645 DP - 2016 May 01 TA - American Journal of Neuroradiology PG - 782--788 VI - 37 IP - 5 4099 - http://www.ajnr.org/content/37/5/782.short 4100 - http://www.ajnr.org/content/37/5/782.full SO - Am. J. Neuroradiol.2016 May 01; 37 AB - BACKGROUND AND PURPOSE: Quantitative susceptibility mapping is useful for assessing iron deposition in the substantia nigra of patients with Parkinson disease. We aimed to determine whether quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference in iron deposits in the substantia nigra of patients with Parkinson disease.MATERIALS AND METHODS: Our study population comprised 24 patients with Parkinson disease and 24 age- and sex-matched healthy controls. They underwent 3T MR imaging by using a 3D multiecho gradient-echo sequence. On reconstructed quantitative susceptibility mapping, we measured the susceptibility values in the anterior, middle, and posterior parts of the substantia nigra, the whole substantia nigra, and other deep gray matter structures in both hemibrains. To identify the more and less affected hemibrains in patients with Parkinson disease, we assessed the severity of movement symptoms for each hemibrain by using the Unified Parkinson's Disease Rating Scale.RESULTS: In the posterior substantia nigra of patients with Parkinson disease, the mean susceptibility value was significantly higher in the more than the less affected hemibrain substantia nigra (P < .05). This value was significantly higher in both the more and less affected hemibrains of patients with Parkinson disease than in controls (P < .05). Asymmetry of the mean susceptibility values was significantly greater for patients than controls (P < .05). Receiver operating characteristic analysis showed that quantitative susceptibility mapping of the posterior substantia nigra in the more affected hemibrain provided the highest power for discriminating patients with Parkinson disease from the controls.CONCLUSIONS: Quantitative susceptibility mapping is useful for assessing the lateral asymmetry and spatial difference of iron deposition in the substantia nigra of patients with Parkinson disease.aSNanterior part of the substantia nigraCNcaudate nucleusGPglobus pallidusmSNmiddle part of the substantia nigraPDParkinson diseasepSNposterior part of the substantia nigraPTputamenQSMquantitative susceptibility mappingRNred nucleusSsusceptibilitySNsubstantia nigraUPDRSUnified Parkinson's Disease Rating Scale