RT Journal Article
SR Electronic
T1 Prevalence of Intracranial Aneurysms in Patients with Aortic Aneurysms
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1664
OP 1668
DO 10.3174/ajnr.A4827
VO 37
IS 9
A1 A. Rouchaud
A1 M.D. Brandt
A1 A.M. Rydberg
A1 R. Kadirvel
A1 K. Flemming
A1 D.F. Kallmes
A1 W. Brinjikji
YR 2016
UL http://www.ajnr.org/content/37/9/1664.abstract
AB BACKGROUND AND PURPOSE: Previous studies have suggested an association between aortic aneurysms and intracranial aneurysms with a higher prevalence of intracranial aneurysms in patients with aortic aneurysms. The aims of the present study were to evaluate the incidence of intracranial aneurysms in a large cohort of patients with aortic aneurysms and to identify potential risk factors for intracranial aneurysms in this population.MATERIALS AND METHODS: We included all patients with aortic aneurysms (either abdominal and/or thoracic) who had available cerebral arterial imaging and were seen at our institution during a 15-year period. We identified patients with intracranial aneurysms. Patient demographics, comorbidities, and aortic aneurysm and intracranial aneurysm sizes and locations were analyzed. Univariate analysis was performed with a χ2 test for categoric variables and a Student t test or ANOVA for continuous variables.RESULTS: A total of 1081 patients with aortic aneurysms were included. Of them, 440 (40.7%) had abdominal aortic aneurysms, 446 (41.3%) had thoracic aortic aneurysms, and 195 (18.0%) had both abdominal aortic and thoracic aortic aneurysms. The overall prevalence of associated intracranial aneurysms in patients with aortic aneurysms was 11.8% (128/1081), with 12.7% (56/440), 10.8% (48/446), and 12.3% (24/195), respectively, in patients with abdominal aortic aneurysms, thoracic aortic aneurysms, and both thoracic aortic aneurysms and abdominal aortic aneurysms. Female patients had a higher risk of associated intracranial aneurysms (OR = 2.08; 95% CI, 1.49–3.03; P = .0002). There was a slight association between abdominal aortic aneurysm size and the prevalence of intracranial aneurysms (OR = 1.02; 95% CI, 1.01–1.03; P = .045). There was no significant association between the locations of the aortic and intracranial aneurysms (P = .93).CONCLUSIONS: The prevalence of intracranial aneurysms is high in patients with aortic aneurysms. Further studies examining the role and cost-effectiveness of intracranial aneurysm screening in patients are warranted.AAaortic aneurysmAAAabdominal aortic aneurysmADPKDautosomal dominant polycystic kidney diseaseIAintracranial aneurysmTAAthoracic aortic aneurysm