RT Journal Article
SR Electronic
T1 Reproducibilty of Magnetization Transfer Ratio Histogram–Derived Measures of the Brainin Healthy Volunteers
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 133
OP 136
VO 21
IS 1
A1 Maria P. Sormani
A1 Giuseppe Iannucci
A1 Maria A. Rocca
A1 Giovanna Mastronardo
A1 Mara Cercignani
A1 Luca Minicucci
A1 Massimo Filippi
YR 2000
UL http://www.ajnr.org/content/21/1/133.abstract
AB Summary: Using two MR scanners, we evaluated the intraobserver, interobserver, image-reimage, and interimager variabilities in the assessment of magnetization transfer ratio (MTR) histograms obtained monthly on four occasions from five healthy volunteers. With multiple observers, the mean coefficients of variations ranged from 2.2% to 8.2% for “pure” image-reimage variability, from 1.2% to 4.9% for interobserver variability, and from 2.1% to 4.9% for image-reimage variability. The mean intraobserver coefficients of variations were always lower than 1%. The mean coefficients of variations ranged from 10.2% to 14.6% for pure interimager variability and from 8.6% to 14.3% for interimager variability with multiple observers. Interimager variability accounted for 96.0% of the overall variability of average MTR, for 96.7% of peak location, and for 41.1% of the peak height. The use of different MR scanners is the main source of variability when obtaining MTR histograms.