RT Journal Article
SR Electronic
T1 Leigh Syndrome in a 3-Year-Old Boy with Unusual Brain MR Imaging and Pathologic Findings
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 224
OP 227
VO 21
IS 1
A1 Meral Topçu
A1 Isil Saatci
A1 R. Anil Apak
A1 Figen Söylemezoglu
A1 Zuhal Akçören
YR 2000
UL http://www.ajnr.org/content/21/1/224.abstract
AB Summary: We report unusual MR serial imaging and electron microscopy findings in a 3-year-old boy who had Leigh syndrome with cytochrome-c oxidase (cox) deficiency. The MR imaging findings included periventricular white matter involvement, posteroanterior progression, and extension through the corpus callosum and internal capsule; however, no basal ganglia or brain stem abnormality was found, which was suggestive of leukodystrophy. The most noteworthy findings were the cystic foci with contrast enhancement in the affected white matter.