TY - JOUR T1 - Leigh Syndrome in a 3-Year-Old Boy with Unusual Brain MR Imaging and Pathologic Findings JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 224 LP - 227 VL - 21 IS - 1 AU - Meral Topçu AU - Isil Saatci AU - R. Anil Apak AU - Figen Söylemezoglu AU - Zuhal Akçören Y1 - 2000/01/01 UR - http://www.ajnr.org/content/21/1/224.abstract N2 - Summary: We report unusual MR serial imaging and electron microscopy findings in a 3-year-old boy who had Leigh syndrome with cytochrome-c oxidase (cox) deficiency. The MR imaging findings included periventricular white matter involvement, posteroanterior progression, and extension through the corpus callosum and internal capsule; however, no basal ganglia or brain stem abnormality was found, which was suggestive of leukodystrophy. The most noteworthy findings were the cystic foci with contrast enhancement in the affected white matter. ER -