RT Journal Article
SR Electronic
T1 Dyslexic Children Have Abnormal Brain Lactate Response to Reading-Related Language Tasks
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1393
OP 1398
VO 20
IS 8
A1 Todd L. Richards
A1 Stephen R. Dager
A1 David Corina
A1 Sandra Serafini
A1 Aaron C. Heide
A1 Keith Steury
A1 Wayne Strauss
A1 Cecil E. Hayes
A1 Robert D. Abbott
A1 Suzanne Craft
A1 Dennis Shaw
A1 Stefan Posse
A1 Virginia W. Berninger
YR 1999
UL http://www.ajnr.org/content/20/8/1393.abstract
AB BACKGROUND AND PURPOSE: Children with dyslexia have difficulty learning to recognize written words owing to subtle deficits in oral language related to processing sounds and accessing words automatically. The purpose of this study was to compare regional changes in brain lactate between dyslexic children and control subjects during oral language activation.METHODS: Brain lactate metabolism was measured during four different cognitive tasks (three language tasks and one nonlanguage task) in six dyslexic boys and in seven control subjects (age- and IQ-matched right-handed boys who are good readers) using a fast MR spectroscopic imaging technique called proton echo-planar spectroscopic imaging (1-cm3 voxel resolution). The area under the N-acetylaspartate (NAA) and lactate peaks was measured to calculate the lactate/NAA ratio in each voxel.RESULTS: Dyslexic boys showed a greater area of brain lactate elevation (2.33 ± SE 0.843 voxels) as compared with the control group (0.57 ± SE 0.30 voxels) during a phonological task in the left anterior quadrant. No significant differences were observed in the nonlanguage tasks.CONCLUSION: Dyslexic and control children differ in brain lactate metabolism when performing language tasks, but do not differ in nonlanguage auditory tasks.