PT  - JOURNAL ARTICLE
AU  - Jean Regis
AU  - Franck Semah
AU  - R. Nick Bryan
AU  - Olivier Levrier
AU  - Marc Rey
AU  - Yves Samson
AU  - Jean-Claude Peragut
TI  - Early and Delayed MR and PET Changes after Selective Temporomesial Radiosurgery in Mesial Temporal Lobe Epilepsy
DP  - 1999 Feb 01
TA  - American Journal of Neuroradiology
PG  - 213--216
VI  - 20
IP  - 2
4099  - http://www.ajnr.org/content/20/2/213.short
4100  - http://www.ajnr.org/content/20/2/213.full
SO  - Am. J. Neuroradiol.1999 Feb 01; 20
AB  - Summary: We report a patient with medically refractory mesial temporal lobe epilepsy treated by gamma knife radiosurgery. In lieu of a microsurgical procedure, an entorhinoamygdalohippocampectomy was performed with a gamma knife and low marginal doses (25 Gy). The clinical and imaging studies, including CT, MR imaging, 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), and long-term follow-up MR examinations, are reported. The patient has been seizure-free since the day of treatment, with no clinical complications. MR studies accurately depicted the effect on the target structures and the transient secondary changes around them. FDG-PET scans showed decreased metabolism after gamma knife surgery throughout the anteromesial part of the epileptogenic temporal lobe. This metabolic decrease was reversible in the lateral temporal cortex. Our case suggests that gamma knife surgery is a promising tool for use as a minimally invasive approach to the treatment of epilepsy.