TY - JOUR T1 - Neonatal Hypoxic-ischemic Encephalopathy: Detection with Diffusion-weighted MR Imaging JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 1490 LP - 1496 VL - 21 IS - 8 AU - Kirsten P. N. Forbes AU - James G. Pipe AU - Roger Bird Y1 - 2000/09/01 UR - http://www.ajnr.org/content/21/8/1490.abstract N2 - BACKGROUND AND PURPOSE: Although diffusion-weighted imaging has been shown to be highly sensitive in detecting acute cerebral infarction in adults, its use in detecting neonatal hypoxic-ischemic encephalopathy (HIE) has not been fully assessed. We examined the ability of this technique to detect cerebral changes of acute neonatal HIE in different brain locations.METHODS: Fifteen MR examinations were performed in 14 neonates with HIE (median age, 6.5 days; range, 2–11 days). Imaging comprised conventional T1-weighted, proton density–weighted, and T2-weighted sequences and echo-planar diffusion-weighted sequences. The location, extent, and image timing of ischemic damage on conventional and diffusion-weighted sequences and apparent diffusion coefficient (ADC) maps were compared.RESULTS: Although conventional sequences showed cerebral changes consistent with ischemia on all examinations, diffusion-weighted imaging showed signal hyperintensity associated with decreased ADC values in only seven subjects (47%). All subjects with isolated cortical infarction on conventional sequences had corresponding hyperintensity on diffusion-weighted images and decreased ADC values, as compared with 14% of subjects with deep gray matter/perirolandic cortical damage. The timing of imaging did not significantly alter diffusion-weighted imaging findings.CONCLUSION: Diffusion-weighted imaging, performed with the technical parameters in this study, may have a lower correlation with clinical evidence of HIE than does conventional MR imaging. The sensitivity of diffusion-weighted imaging in detecting neonatal HIE appears to be affected by the pattern of ischemic damage, with a lower sensitivity if the deep gray matter is affected as compared with isolated cerebral cortex involvement. ER -