@article {Boecher-Schwarz1532, author = {Hans G. Boecher-Schwarz and Kurt Ringel and Laszlo Kopacz and Axel Heimann and Oliver Kempski}, title = {Ex Vivo Study of the Physical Effect of Coils on Pressure and Flow Dynamics in Experimental Aneurysms}, volume = {21}, number = {8}, pages = {1532--1536}, year = {2000}, publisher = {American Journal of Neuroradiology}, abstract = {BACKGROUND AND PURPOSE: Recent experimental studies and a few case reports reveal that coiling may not lead to permanent occlusion of aneurysms by an organized thrombus. Therefore, biologic long-term prognosis seems to be doubtful, and the physical effect of coils may be important. The purpose of this study was to investigate the physical effect of coils on pressure and flow dynamics in aneurysms.METHODS: Bifurcation aneurysms were created in eight rabbits, explanted after 3 weeks, and tested in a model with pulsatile perfusion with 0.9\% saline and heparinized blood. Before and after densely packing with coils, systemic and intraaneurysmal pressure, aneurysmal pulsation, and impact measurements were recorded.RESULTS: The peak and shape of the pressure waves in the aneurysm and in the delivery system were not significantly different before and after coiling. Under physiological intraaneurysmal pressure (while being perfused with saline), significant reduction (P = .022) of aneurysmal wall pulsation after coil embolization was noted. Overall, the aneurysmal impact on surrounding structures was statistically unchanged after coiling. However, in a few cases, after coil embolization, the observed increase of impact was more than doubled compared with the original values before coiling.CONCLUSION: Coils do not physically affect intraaneurysmal pressure. After coiling, there is no significant reduction of flow rates through the aneurysm and no reduction of aneurysmal impact, but aneurysmal wall pulsation may be decreased.}, issn = {0195-6108}, URL = {https://www.ajnr.org/content/21/8/1532}, eprint = {https://www.ajnr.org/content/21/8/1532.full.pdf}, journal = {American Journal of Neuroradiology} }