RT Journal Article SR Electronic T1 The Role of Diffusion-weighted Imaging in Patients with Brain Tumors JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 1081 OP 1088 VO 22 IS 6 A1 Kinuko Kono A1 Yuichi Inoue A1 Keiko Nakayama A1 Miyuki Shakudo A1 Michiharu Morino A1 Kenji Ohata A1 Kenichi Wakasa A1 Ryusaku Yamada YR 2001 UL http://www.ajnr.org/content/22/6/1081.abstract AB BACKGROUND AND PURPOSE: Diffusion-weighted images (DWIs) have been used to study various diseases, particularly since echo-planar techniques shorten examination time. Our hypothesis was that DWIs and tumor apparent diffusion coefficients (ADCs) could provide additional useful information in the diagnosis of patients with brain tumors.METHODS: Using a 1.5-T MR unit, we examined 56 patients with histologically verified or clinically diagnosed brain tumors (17 gliomas, 21 metastatic tumors, and 18 meningiomas). We determined ADC values and signal intensities on DWIs both in the solid portion of the tumor and in the peritumoral, hyperintense areas on T2-weighted images. We also evaluated the correlation between ADC values and tumor cellularity in both gliomas and meningiomas.RESULTS: The ADCs of low-grade (grade II) astrocytomas were significantly higher (P = .0004) than those of other tumors. Among astrocytic tumors, ADCs were higher in grade II astrocytomas (1.14 ± 0.18) than in glioblastomas (0.82 ± 0.13). ADCs and DWIs were not useful in determining the presence of peritumoral neoplastic cell infiltration. The ADC values correlated with tumor cellularity for both astrocytic tumors (r = −.77) and meningiomas (r = −.67).CONCLUSION: The ADC may predict the degree of malignancy of astrocytic tumors, although there is some overlap between ADCs of grade II astrocytomas and glioblastomas.