TY - JOUR T1 - Cortical Involvement in Marchiafava-Bignami Disease JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 670 LP - 673 VL - 26 IS - 3 AU - Ken Johkura AU - Makoto Naito AU - Takayuki Naka Y1 - 2005/03/01 UR - http://www.ajnr.org/content/26/3/670.abstract N2 - Summary: Marchiafava-Bignami disease (MBD), a rare complication of chronic alcoholism, is characterized by primary demyelination of the corpus callosum. We report two cases of MBD in which fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging studies revealed symmetrical hyperintense lesions in the cerebral cortex (particularly in the lateral-frontal regions) in addition to the callosal lesions, which suggests an association of diffuse cortical lesions such as Morel’s laminar sclerosis with MBD. ER -