@article {Ding2364, author = {Yong Hong Ding and Daying Dai and Debra A. Lewis and Mark A. Danielson and Ramanathan Kadirvel and Jayawant N. Mandrekar and Harry J. Cloft and David F. Kallmes}, title = {Can Neck Size in Elastase-Induced Aneurysms Be Controlled? A Prospective Study}, volume = {26}, number = {9}, pages = {2364--2367}, year = {2005}, publisher = {American Journal of Neuroradiology}, abstract = {BACKGROUND AND PURPOSE: An earlier retrospective study indicated that the neck size of elastase-induced aneurysms could be controlled by adjusting the position of the inflated balloon. We report the current prospective study to confirm our previous work.METHODS: Ninety elastase-induced aneurysms were created in rabbits. Group 1 (n = 62) included cases in which the occlusion balloon resided low, completely within the brachiocephalic/subclavian arteries. Group 2 (n = 28) included cases in which the balloon resided high, within both the common carotid artery and brachiocephalic/subclavian arteries. Follow-up digital subtraction angiography was performed. The aneurysm sizes were measured and compared between groups. The Student t test and the Fisher exact test were used for statistical analysis.RESULTS: The mean aneurysm neck diameter and width for group 1 was significantly larger than that of group 2 (3.4 {\textpm} 1.2 and 2.3 {\textpm} 0.9 mm, P \< .001; 3.8 {\textpm} 1.0 and 3.3 {\textpm} 0.9 mm, P \< .05, respectively). The proportion of wide-necked aneurysms in group 1 was significantly larger than that in group 2 (29\% vs 4\%; P \< .005). Mean dome-to-neck ratios were 1.2 {\textpm} 0.4 and 1.7 {\textpm} 0.7 for groups 1 and 2 (P \< .005). There was no significant difference in aneurysm height between groups 1 and 2 (8.0 {\textpm} 1.7 and 7.5 {\textpm} 2.2 mm; P \> .05).CONCLUSION: The neck size of elastase-induced aneurysm models in rabbits can be controlled by adjusting the position of the inflated balloon.}, issn = {0195-6108}, URL = {https://www.ajnr.org/content/26/9/2364}, eprint = {https://www.ajnr.org/content/26/9/2364.full.pdf}, journal = {American Journal of Neuroradiology} }