RT Journal Article
SR Electronic
T1 Can Neck Size in Elastase-Induced Aneurysms Be Controlled? A Prospective Study
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2364
OP 2367
VO 26
IS 9
A1 Yong Hong Ding
A1 Daying Dai
A1 Debra A. Lewis
A1 Mark A. Danielson
A1 Ramanathan Kadirvel
A1 Jayawant N. Mandrekar
A1 Harry J. Cloft
A1 David F. Kallmes
YR 2005
UL http://www.ajnr.org/content/26/9/2364.abstract
AB BACKGROUND AND PURPOSE: An earlier retrospective study indicated that the neck size of elastase-induced aneurysms could be controlled by adjusting the position of the inflated balloon. We report the current prospective study to confirm our previous work.METHODS: Ninety elastase-induced aneurysms were created in rabbits. Group 1 (n = 62) included cases in which the occlusion balloon resided low, completely within the brachiocephalic/subclavian arteries. Group 2 (n = 28) included cases in which the balloon resided high, within both the common carotid artery and brachiocephalic/subclavian arteries. Follow-up digital subtraction angiography was performed. The aneurysm sizes were measured and compared between groups. The Student t test and the Fisher exact test were used for statistical analysis.RESULTS: The mean aneurysm neck diameter and width for group 1 was significantly larger than that of group 2 (3.4 ± 1.2 and 2.3 ± 0.9 mm, P < .001; 3.8 ± 1.0 and 3.3 ± 0.9 mm, P < .05, respectively). The proportion of wide-necked aneurysms in group 1 was significantly larger than that in group 2 (29% vs 4%; P < .005). Mean dome-to-neck ratios were 1.2 ± 0.4 and 1.7 ± 0.7 for groups 1 and 2 (P < .005). There was no significant difference in aneurysm height between groups 1 and 2 (8.0 ± 1.7 and 7.5 ± 2.2 mm; P > .05).CONCLUSION: The neck size of elastase-induced aneurysm models in rabbits can be controlled by adjusting the position of the inflated balloon.