@article {Sage893, author = {M R Sage and J Wilcox and C A Evill and G T Benness}, title = {Comparison of blood-brain barrier disruption by intracarotid iopamidol and methylglucamine iothalamate.}, volume = {4}, number = {4}, pages = {893--895}, year = {1983}, publisher = {American Journal of Neuroradiology}, abstract = {Using a canine model, the effect of intracarotid injections of the ionic contrast medium methylglucamine iothalamate was compared with that of the nonionic contrast medium iopamidol of similar iodine concentration (280 mg 1/ml). The degree and distribution of blood-brain barrier disruption was assessed using Evans blue stain as a visual marker and by contrast enhancement measured by a computed tomographic (CT) scanner. In all studies with methylglucamine iothalamate, Evans blue staining was demonstrated, and CT enhancement demonstrated a significant mean difference (p less than 0.01) between the control and injected hemispheres. The absence of blood-brain barrier disruption with iopamidol is probably related to its lower osmolality (570 mosmol/kg) compared with methylglucamine iothalamate (1,424 mosmol/kg) and the absence of any cation.}, issn = {0195-6108}, URL = {https://www.ajnr.org/content/4/4/893}, eprint = {https://www.ajnr.org/content/4/4/893.full.pdf}, journal = {American Journal of Neuroradiology} }