%0 Journal Article %A M R Sage %A J Wilcox %A C A Evill %A G T Benness %T Comparison of blood-brain barrier disruption by intracarotid iopamidol and methylglucamine iothalamate. %D 1983 %J American Journal of Neuroradiology %P 893-895 %V 4 %N 4 %X Using a canine model, the effect of intracarotid injections of the ionic contrast medium methylglucamine iothalamate was compared with that of the nonionic contrast medium iopamidol of similar iodine concentration (280 mg 1/ml). The degree and distribution of blood-brain barrier disruption was assessed using Evans blue stain as a visual marker and by contrast enhancement measured by a computed tomographic (CT) scanner. In all studies with methylglucamine iothalamate, Evans blue staining was demonstrated, and CT enhancement demonstrated a significant mean difference (p less than 0.01) between the control and injected hemispheres. The absence of blood-brain barrier disruption with iopamidol is probably related to its lower osmolality (570 mosmol/kg) compared with methylglucamine iothalamate (1,424 mosmol/kg) and the absence of any cation. %U https://www.ajnr.org/content/ajnr/4/4/893.full.pdf