PT - JOURNAL ARTICLE AU - M R Sage AU - J Wilcox AU - C A Evill AU - G T Benness TI - Comparison of blood-brain barrier disruption by intracarotid iopamidol and methylglucamine iothalamate. DP - 1983 Jul 01 TA - American Journal of Neuroradiology PG - 893--895 VI - 4 IP - 4 4099 - http://www.ajnr.org/content/4/4/893.short 4100 - http://www.ajnr.org/content/4/4/893.full SO - Am. J. Neuroradiol.1983 Jul 01; 4 AB - Using a canine model, the effect of intracarotid injections of the ionic contrast medium methylglucamine iothalamate was compared with that of the nonionic contrast medium iopamidol of similar iodine concentration (280 mg 1/ml). The degree and distribution of blood-brain barrier disruption was assessed using Evans blue stain as a visual marker and by contrast enhancement measured by a computed tomographic (CT) scanner. In all studies with methylglucamine iothalamate, Evans blue staining was demonstrated, and CT enhancement demonstrated a significant mean difference (p less than 0.01) between the control and injected hemispheres. The absence of blood-brain barrier disruption with iopamidol is probably related to its lower osmolality (570 mosmol/kg) compared with methylglucamine iothalamate (1,424 mosmol/kg) and the absence of any cation.