PT  - JOURNAL ARTICLE
AU  - J R Fike
AU  - C E Cann
AU  - D Norman
AU  - J M Turrel
AU  - R A LeCouteur
AU  - C M Pflugfelder
AU  - J K Borcich
TI  - Relative uptake of low- and high-osmolality contrast media in CT of brain tumors.
DP  - 1984 Jul 01
TA  - American Journal of Neuroradiology
PG  - 413--417
VI  - 5
IP  - 4
4099  - http://www.ajnr.org/content/5/4/413.short
4100  - http://www.ajnr.org/content/5/4/413.full
SO  - Am. J. Neuroradiol.1984 Jul 01; 5
AB  - The magnitude and time course of contrast enhancement in spontaneous canine brain tumors was determined for two contrast agents: meglumine iothalamate and sodium meglumine ioxaglate. Tumor enhancement during contrast infusion and at 5, 10, 15, 30, and 45 min was measured using quantitative computed tomography. Blood iodine was measured using x-ray fluorescence. Peak contrast enhancement occurred during the infusion, and the magnitude was the same for both agents. Per gram of iodine infused, blood iodine was 12.4% higher with ioxaglate than iothalamate. The monoionic dimer ioxaglate is as effective as iothalamate for enhancement of canine brain tumors.