%0 Journal Article %A P Floras %A A M Bidabé %A J M Caillé %A G Simonnet %A J M Lecomte %A M Sabathié %T Double-blind study of effects of enkephalinase inhibitor on adverse reactions to myelography. %D 1983 %J American Journal of Neuroradiology %P 653-655 %V 4 %N 3 %X The side effects in myelography are well known and frequently observed. The most common are headache, nausea, and vomiting. In this study, a rather new compound, Thiorphan, was examined, which displays an antinociceptive activity by inhibiting enkephalinase activity. Forty-two patients received intravenous infusions of Thiorphan before myelography. Another 42 patients were in a control group, and Thiorphan was not administered. In the treated group, postmyelographic headache was found in 24% (versus 52% in the control group). Nausea and vomiting were never seen. Low back pain or sciatica was diminished in 33% of cases. Enkephalin levels in cerebrospinal fluid were measured by a radioreceptor-assay method in both groups without any correlation. %U https://www.ajnr.org/content/ajnr/4/3/653.full.pdf