TY - JOUR T1 - Double-blind study of effects of enkephalinase inhibitor on adverse reactions to myelography. JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. SP - 653 LP - 655 VL - 4 IS - 3 AU - P Floras AU - A M Bidabé AU - J M Caillé AU - G Simonnet AU - J M Lecomte AU - M Sabathié Y1 - 1983/05/01 UR - http://www.ajnr.org/content/4/3/653.abstract N2 - The side effects in myelography are well known and frequently observed. The most common are headache, nausea, and vomiting. In this study, a rather new compound, Thiorphan, was examined, which displays an antinociceptive activity by inhibiting enkephalinase activity. Forty-two patients received intravenous infusions of Thiorphan before myelography. Another 42 patients were in a control group, and Thiorphan was not administered. In the treated group, postmyelographic headache was found in 24% (versus 52% in the control group). Nausea and vomiting were never seen. Low back pain or sciatica was diminished in 33% of cases. Enkephalin levels in cerebrospinal fluid were measured by a radioreceptor-assay method in both groups without any correlation. ER -