RT Journal Article SR Electronic T1 MR findings in methotrexate-induced CNS abnormalities. JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 959 OP 964 VO 10 IS 5 A1 F Ebner A1 G Ranner A1 I Slavc A1 C Urban A1 R Kleinert A1 H Radner A1 R Einspieler A1 E Justich YR 1989 UL http://www.ajnr.org/content/10/5/959.abstract AB MR of the brain was performed in eight patients (mean age, 14.9 years) with osteogenic sarcoma during or after IV treatment with high-dose methotrexate. MR detected brain abnormalities in four patients, three of whom had concomitant neurologic dysfunction. Pathologic findings demonstrated on MR were (1) chronic brain edema, demonstrable over a period of 3-14 months (proved by autopsy in one patient); (2) multifocal white matter necrosis; and (3) deep brain atrophy. MR appears to be valuable in the detection of abnormalities induced by treatment with high-dose methotrexate.