PT  - JOURNAL ARTICLE
AU  - Y Kaneoke
AU  - M Furuse
AU  - K Yoshida
AU  - K Saso
AU  - K Ichihara
AU  - Y Motegi
TI  - Transfer index of MR relaxation enhancer: a quantitative evaluation of MR contrast enhancement.
DP  - 1989 Mar 01
TA  - American Journal of Neuroradiology
PG  - 329--333
VI  - 10
IP  - 2
4099  - http://www.ajnr.org/content/10/2/329.short
4100  - http://www.ajnr.org/content/10/2/329.full
SO  - Am. J. Neuroradiol.1989 Mar 01; 10
AB  - To clarify the effects of Gd-DTPA on biological water, we examined the effects of the compound on spin-lattice relaxation rate with various concentrations of gelatin solutions. The results indicate that the effects of relaxation rate of Gd-DTPA in biological water fundamentally correspond to those in aqueous solution. To evaluate the distribution of Gd-DTPA in tissues, we introduced a transfer index that represents the product of tissue-blood ratio of Gd-DTPA and the ratio of extracellular volume of a tissue based on the above findings. The index depends neither on dose of the compound nor on Larmor frequency. The clinical significance of the index was studied in patients with brain tumors. The indexes varied from 0.038 to 0.51, depending on the biological characteristics of the tumors. The transfer index may be used in the quantitative evaluation of MR relaxation enhancement, which may be applied to monitoring therapeutic efficacy and to estimating tissue perfusion.