RT Journal Article
SR Electronic
T1 MR and proton MR spectroscopy of the brain in hyperhomocysteinemia caused by methylenetetrahydrofolate reductase deficiency.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 536
OP 539
VO 18
IS 3
A1 V Engelbrecht
A1 M Rassek
A1 J Huismann
A1 U Wendel
YR 1997
UL http://www.ajnr.org/content/18/3/536.abstract
AB MR imaging showed severe atrophy and large areas without myelination in the brain of a girl with methylenetetrahydrofolate reductase deficiency. Proton MR spectroscopy revealed mild signal reduction of N-acetylaspartate. After treatment with betaine, a second MR imaging study revealed a decrease in the size of the hypomyelinated zones that was paralleled by improved clinical status and laboratory findings.