PT  - JOURNAL ARTICLE
AU  - Y Kato
AU  - K Matsumura
AU  - Y Kinosada
AU  - Y Narita
AU  - S Kuzuhara
AU  - T Nakagawa
TI  - Detection of pyramidal tract lesions in amyotrophic lateral sclerosis with magnetization-transfer measurements.
DP  - 1997 Sep 01
TA  - American Journal of Neuroradiology
PG  - 1541--1547
VI  - 18
IP  - 8
4099  - http://www.ajnr.org/content/18/8/1541.short
4100  - http://www.ajnr.org/content/18/8/1541.full
SO  - Am. J. Neuroradiol.1997 Sep 01; 18
AB  - PURPOSE To determine the presence of small lesions in the pyramidal tract in patients with amyotrophic lateral sclerosis (ALS) by using magnetization-transfer (MT) measurements and MR imaging.METHODS MT ratios (MTRs) were measured in the posterior limb of the internal capsule in nine patients with ALS and in nine healthy volunteers.RESULTS The mean value of MTRs (%) in patients with ALS was 15.76 +/- 1.48, while that of the control subjects was 19.83 +/- 1.54. The difference was statistically significant.CONCLUSIONS MT measurements are useful for detecting abnormalities associated with degeneration of the pyramidal tract in patients with ALS.