PT  - JOURNAL ARTICLE
AU  - C Claussen
AU  - M Laniado
AU  - W Schörner
AU  - H P Niendorf
AU  - H J Weinmann
AU  - W Fiegler
AU  - R Felix
TI  - Gadolinium-DTPA in MR imaging of glioblastomas and intracranial metastases.
DP  - 1985 Sep 01
TA  - American Journal of Neuroradiology
PG  - 669--674
VI  - 6
IP  - 5
4099  - http://www.ajnr.org/content/6/5/669.short
4100  - http://www.ajnr.org/content/6/5/669.full
SO  - Am. J. Neuroradiol.1985 Sep 01; 6
AB  - In 14 patients with the diagnosis of glioblastoma (n = 7) or intracranial metastases (n = 7), magnetic resonance (MR) imaging was performed using a variety of spin-echo (SE) pulse sequences before and after intravenous injection of 0.1 mmol gadolinium-DTPA (Gd-DTPA) per kilogram of body weight. In 10 patients, tumor tissue could not be adequately differentiated from perifocal edema on unenhanced scans with any of the applied pulse sequences. In four cases of intracranial metastases, poor differentiation between tumor and perifocal edema was possible in T2-weighted (SE 1600/70 and SE 1600/105) unenhanced scans. After administration of Gd-DTPA, tumor tissue showed marked contrast enhancement, and tumor delineation was consistently possible on SE 800/35 images. Tumor tissue could be differentiated from perifocal edema on SE 800/70 scans. Gd-DTPA is likely to increase the potential of MR imaging and refine the evaluation of glioblastomas and intracerebral metastases.