PT  - JOURNAL ARTICLE
AU  - R E Latchaw
AU  - W L Hirsch, Jr
AU  - J A Horton
AU  - D Bissonette
AU  - D D Shaw
TI  - Iohexol vs. metrizamide: study of efficacy and morbidity in cervical myelography.
DP  - 1985 Nov 01
TA  - American Journal of Neuroradiology
PG  - 931--933
VI  - 6
IP  - 6
4099  - http://www.ajnr.org/content/6/6/931.short
4100  - http://www.ajnr.org/content/6/6/931.full
SO  - Am. J. Neuroradiol.1985 Nov 01; 6
AB  - A double-blind study was conducted in 60 patients undergoing either cervical or more complete myelography via C1-C2 puncture. Patients received either iohexol or metrizamide at a 300 mg l/ml concentration. The contrast media were equally efficacious in the production of high-quality radiographs and CT scans. However, the incidence of adverse reactions differed markedly. Of patients receiving metrizamide, 68% had some type of adverse reaction, whereas only 26% receiving iohexol had symptoms. The incidence of headache (metrizamide, 34%; iohexol, 26%) was not statistically different, but the quality of the headache differed: half of the metrizamide headaches were moderate or severe, whereas all iohexol headaches were mild. Nausea (31%) and vomiting (28%) were common with metrizamide but unusual (3% nausea) with iohexol. Of the metrizamide patients, 21% had overt psychologic changes that did not occur in the iohexol group.