RT Journal Article SR Electronic T1 MR imaging of the optic nerve and sheath: correcting the chemical shift misregistration effect. JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 249 OP 253 VO 7 IS 2 A1 D L Daniels A1 J B Kneeland A1 A Shimakawa A1 K W Pojunas A1 J F Schenck A1 H Hart, Jr A1 T Foster A1 A L Williams A1 V M Haughton YR 1986 UL http://www.ajnr.org/content/7/2/249.abstract AB The interface between soft-tissue structures and adipose tissue may be obscured by the chemical shift misregistration effect on MR images. In the orbit, this effect occurs at the edges at the optic nerve, even on high-resolution local coil images. In both phantom and clinical studies with a 1.5 T local coil imaging system, it was found that the chemical shift misregistration effect can be minimized by positioning the patient so that the optic nerve is parallel to the frequency encoding gradient. Alternatively, the effect can be corrected by using a computer program to combine "lipid" and "water" proton images. The sensitivity of MR for optic nerve lesions should be improved by these technical modifications.