PT  - JOURNAL ARTICLE
AU  - W A Cohen
AU  - W Young
AU  - V DeCrescito
AU  - S Horii
AU  - I I Kricheff
TI  - Posttraumatic syrinx formation: experimental study.
DP  - 1985 Sep 01
TA  - American Journal of Neuroradiology
PG  - 823--827
VI  - 6
IP  - 5
4099  - http://www.ajnr.org/content/6/5/823.short
4100  - http://www.ajnr.org/content/6/5/823.full
SO  - Am. J. Neuroradiol.1985 Sep 01; 6
AB  - An experimental study was performed to examine posttraumatic spinal cord cavitation in an animal model by evaluating immediate and delayed computed tomographic (CT) scans obtained after administration of intrathecal contrast material. Four cats underwent midthoracic laminectomy and spinal cord contusion using a standard 400 g-cm model. All animals were studied by CT with intrathecal contrast enhancement before and 4-5 days, 3-4 weeks, and 7-13 weeks after experimental cord contusion. Either metrizamide or iopamidol was used as the contrast agent. Two of the four cats had CT and pathologic evidence of cord cavitation at the site of injury. Another animal had uptake of contrast material into the spinal cord without pathologic evidence of cyst formation, which was believed to represent malacic change. The fourth animal had a normal-appearing cord by both CT and pathologic criteria. Animals that received metrizamide after cord contusion had generalized myoclonic seizures. This did not occur when iopamidol was administered.