PT - JOURNAL ARTICLE AU - W H McAlister AU - V I McAlister AU - J M Kissane TI - The effect of Gd-dimeglumine on subcutaneous tissues: a study with rats. DP - 1990 Mar 01 TA - American Journal of Neuroradiology PG - 325--327 VI - 11 IP - 2 4099 - http://www.ajnr.org/content/11/2/325.short 4100 - http://www.ajnr.org/content/11/2/325.full SO - Am. J. Neuroradiol.1990 Mar 01; 11 AB - Gadopentetate dimeglumine and a saline solution of similar osmolality of 2100 mOs/kg H2O were placed in the paws and in the thigh muscles and subcutaneous tissue of Sprague-Dawley rats weighing 225-250 g. The paws were serially photographed for 4 weeks and the thighs were examined histologically for up to 4 weeks. Gross and histologic reactions to gadopentetate dimeglumine were greater than those to the saline solution, and included tissue sloughs. When risk factors for extravascular extravasation are present, such as infusion sites in the dorsum of the hand or foot, or around the ankle, or when soft tissues are obscured by bandages, caution should be exercised when injecting gadopentetate dimeglumine.