TY - JOUR T1 - Clopidogrel (Plavix) JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. DO - 10.3174/ajnr.A2913 AU - J. Comin AU - D. Kallmes Y1 - 2011/11/30 UR - http://www.ajnr.org/content/early/2011/12/01/ajnr.A2913.abstract N2 - SUMMARY: Clopidogrel is an inhibitor of platelet aggregation, indicated for the prevention of ischemic stroke and in-stent thrombosis. However, it has a number of drawbacks, including an increased risk of hemorrhage; a clinical effect that is slow in onset and irreversible; a genetically determined variability in its clinical potency; and interactions with other commonly administered drugs. Abbreviations Act-Metactive metabolite of clopidogrelADPadenosine diphosphateAHAAmerican Hospital AssociationGIgastrointestinalGPIIb/IIIaglycoprotein IIb/IIIaPPIproton pump inhibitorVWFvon Willebrand factor ER -