PT - JOURNAL ARTICLE AU - H.A. Deutschmann AU - M. Wehrschuetz AU - M. Augustin AU - K. Niederkorn AU - G.E. Klein TI - Long-Term Follow-Up after Treatment of Intracranial Aneurysms with the Pipeline Embolization Device: Results from a Single Center AID - 10.3174/ajnr.A2790 DP - 2011 Dec 07 TA - American Journal of Neuroradiology 4099 - http://www.ajnr.org/content/early/2011/12/08/ajnr.A2790.short 4100 - http://www.ajnr.org/content/early/2011/12/08/ajnr.A2790.full AB - BACKGROUND AND PURPOSE: Stent-like, self-expandable devices, the so-called flow diverters, are increasingly used for the treatment of wide-neck cerebral aneurysms. The immediate and short-term results are promising, but no long-term results are available. The purpose of our research was to report the long-term angiographic and cross-sectional imaging results after placement of a PED in 12 patients with wide-neck intracranial aneurysms. MATERIALS AND METHODS: Twelve wide-neck or otherwise untreatable cerebral aneurysms in 12 patients were treated with the PED. Angiography was performed at 6 and 24 months after treatment. Additional MR and CT angiograms were acquired. RESULTS: In all patients, angiographic or cross-sectional imaging follow-up of at least 27 months demonstrated complete occlusion of the aneurysms treated with the PED. There were no cases of aneurysm recurrence. Angiography at around 6 months showed complete occlusion in all cases, except 1 that showed complete occlusion at the 29-month follow-up. In 1 patient, a clinically asymptomatic 75% in-stent stenosis was seen on the angiography at 6 months but was resolved completely by balloon dilation. Device placement was successful in all patients. Distal embolization had occurred in 1 patient, but the clot was resolved completely without clinical sequelae. Almost immediate angiographic occlusion was achieved in 2 aneurysms and flow reduction in 10 aneurysms. CONCLUSIONS: Treatment of wide-neck intracranial aneurysms by PED placement led to successful and durable occlusion in all cases, without severe complications. Endovascular treatment for in-stent stenosis should be considered cautiously, because the underlying stenosis may be transient and disappear within 12 months after treatment. Abbreviations CPRcurved planar reconstructionGOSGlasgow Outcome ScalePcomAposterior communicating arteryPEDPipeline Embolization DevicePITAPipeline for the Intracranial Treatment of Aneurysms