RT Journal Article
SR Electronic
T1 Functional and Structural MR Imaging in Neuropsychiatric Disorders, Part 1: Imaging Techniques and Their Application in Mild Cognitive Impairment and Alzheimer Disease
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A2799
A1 S. Mueller
A1 D. Keeser
A1 M.F. Reiser
A1 S. Teipel
A1 T. Meindl
YR 2011
UL http://www.ajnr.org/content/early/2011/12/15/ajnr.A2799.abstract
AB SUMMARY: During the past decade, the application of advanced MR imaging techniques in neuropsychiatric disorders has seen a rapid increase. Disease-specific alterations in brain function can be assessed by fMRI. Structural GM and WM properties are increasingly investigated by DTI and voxel-based approaches like VBM. These methods provide neurobiologic correlates for brain architecture and function, evaluation tools for therapeutic approaches, and potential early markers for diagnosis. The aim of this review was to provide insight into the principles of functional and structural imaging and to delineate major findings in MCI, AD (Part 1), autism, and schizophrenia (Part 2), which are common psychiatric disorders covering different stages of the life span. Part 2 will conclude by summarizing current applications, limitations, and future prospects in the field of MR imaging−based neuroimaging. Abbreviations ACCanterior cingulate cortexADAlzheimer diseaseASDautism spectrum disordersBOLDblood oxygen level–dependentDMNdefault mode networkEEGelectroencephalographyFAfractional anisotropyGMgray matterICAindependent component analysisMCImild cognitive impairmentMDmean diffusivityPCCposterior cingulate cortexrsfMRIresting-state fMRIVBMvoxel-based morphometry