TY - JOUR T1 - Ultrasound-Based Diagnostic Classification for Solid and Partially Cystic Thyroid Nodules JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. DO - 10.3174/ajnr.A2923 AU - D.W. Kim AU - J.S. Park AU - H.S. In AU - H.J. Choo AU - J.H. Ryu AU - S.J. Jung Y1 - 2012/02/02 UR - http://www.ajnr.org/content/early/2012/02/02/ajnr.A2923.abstract N2 - BACKGROUND AND PURPOSE: The ability of US to differentiate benign thyroid nodules from malignant ones is still a matter of debate. The aim of this study was to assess the diagnostic efficacy of a US-based classification system for solid and PCTNs through a prospectively designed study. MATERIALS AND METHODS: We studied 1289 thyroid nodules in 1036 patients who underwent thyroid US, US-FNA, and thyroid surgery. Each thyroid nodule was prospectively classified into 1 of 5 diagnostic categories following real-time US examination: benign, probably benign, borderline, possibly malignant, and malignant. Solid nodules were classified by using all 5 categories, and PCTNs were classified by all except the borderline category. We calculated the diagnostic efficacy of thyroid US by comparing US diagnoses with histopathologic results of surgically resected thyroid nodules. RESULTS: One thousand fifty-five solid nodules and 234 PCTNs were prospectively classified as benign (n = 435 and 179), probably benign (n = 213 and 25), borderline (n = 94 and 0), possibly malignant (n = 115 and 15), and malignant (n = 198 and 15), respectively. Of these 1289 nodules, 505 were surgically resected and confirmed by pathology (191 benign and 314 malignant nodules); there were 44 resected solid nodules with a borderline category. For solid nodules and PCTNs, the sensitivity, specificity, positive and negative predictive values, and accuracy of US diagnosis were 86.1 and 66.7, 90.0 and 88.9, 94.3 and 75.0, 77.3 and 84.2, and 87.5% and 81.5%, respectively, based on 505 surgical specimens and excluding the 42 solid borderline nodules. CONCLUSIONS: Our US-based classification system can provide helpful guidance for the management of thyroid nodules. Abbreviations FNAfine-needle aspirationPCTNpartially cystic thyroid nodulePCTN-USUS class of partially cystic thyroid noduleSN-US classUS class of solid noduleUSsonography ER -