PT  - JOURNAL ARTICLE
AU  - H. Kato
AU  - E. Shimosegawa
AU  - K. Isohashi
AU  - N. Kimura
AU  - H. Kazui
AU  - J. Hatazawa
TI  - Distribution of Cortical Benzodiazepine Receptor Binding in Right-Handed Healthy Humans: A Voxel-Based Statistical Analysis of Iodine 123 Iomazenil SPECT with Partial Volume Correction
AID  - 10.3174/ajnr.A3005
DP  - 2012 Mar 08
TA  - American Journal of Neuroradiology
4099  - http://www.ajnr.org/content/early/2012/03/08/ajnr.A3005.short
4100  - http://www.ajnr.org/content/early/2012/03/08/ajnr.A3005.full
AB  - BACKGROUND AND PURPOSE: CBR imaging is highly susceptible to a PVE produced by morphologic changes in the brain related to aging and brain laterality. We assessed the influence of PVE produced by regional age-related changes in gray matter volume on I-123 iomazenil SPECT and elucidated the age-related changes in human CBR binding by using PVE-corrected SPECT images. MATERIALS AND METHODS: Nineteen right-handed healthy volunteers (range, 25–82 years; mean, 55 ± 21 years) underwent MR imaging and quantitative I-123 iomazenil SPECT imaging. The influence of age-related changes in rGMC on SPECT images before PVE correction was assessed. PVE correction of the SPECT images was performed by using an MR imaging–based method. Voxel-based linear regression analyses of the PVE-corrected SPECT images were performed by using SPM5. RESULTS: The age-related reductions in rGMC and BP without PVE correction revealed a significant direct proportional correlation. Voxel-based statistical analysis with PVE correction showed no significant age-related changes in BP. CONCLUSIONS: PVE correction was indispensable for the analysis of I-123 iomazenil SPECT images. PVE-corrected quantitative I-123 iomazenil SPECT images revealed no age-related changes in CBR binding in right-handed healthy humans. Abbreviations AALautomated anatomic labelingBPbinding potentialCBRcentral benzodiazepine receptorFWHMfull width at half maximumI-123iodine 123PSFpoint-spreading functionPVEpartial volume effectrGMCregional gray matter concentrationSPMstatistical parametric mappingVBMvoxel-based morphometry