TY - JOUR T1 - Do Early MRI Signals Predict Lesion Size in a Neonatal Stroke Rat Model? JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. DO - 10.3174/ajnr.A3069 AU - S. Fau AU - C. Po AU - C. Goyenvalle AU - P. Meric AU - C. Charriaut-Marlangue Y1 - 2012/05/03 UR - http://www.ajnr.org/content/early/2012/05/03/ajnr.A3069.abstract N2 - SUMMARY: In this study, we compared lesion size by using VADC and VT2 at 0, 2, 5, 24, and 48 hours and histologic lesions at 48 hours in a P7 rat stroke model. The best correlation between VHISTO and VADC was at H0, and between VHISTO and VT2, at H2-H5. Early MR imaging signals allowed excluding “no-lesion” and “no-reflow” animals to help standardize this neonatal stroke model and predict lesion size. Abbreviations H0, H2, H5, H24, and H4815 minutes and 2, 5, 24, and 48 hours after reperfusion, respectivelyP77-day-oldRARErapid acquisition relaxation excitementVADCvolume of lesion on ADC mapsVHISTOvolume of lesion on histologic sectionsVT2volume of lesion on T2 maps ER -