TY - JOUR T1 - Reduced Diffusion in a Subset of Acute MS Lesions: A Serial Multiparametric MRI Study JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. DO - 10.3174/ajnr.A2975 AU - P. Eisele AU - K. Szabo AU - M. Griebe AU - C. Roßmanith AU - A. Förster AU - M. Hennerici AU - A. Gass Y1 - 2012/05/10 UR - http://www.ajnr.org/content/early/2012/05/10/ajnr.A2975.abstract N2 - BACKGROUND AND PURPOSE: MRI studies have focused on newly developing MS lesions to characterize the early pathology of the disease. DWI is highly sensitive to acute and chronic tissue changes in MS. We characterized the development of acute MS lesions by using DWI in a multiparametric MRI protocol. MATERIALS AND METHODS: Seventy-two consecutive patients presenting with a new symptom with definite MS or a CIS suggestive of central nervous system demyelination were screened with MRI. Patients who showed an acute MRI lesion with a reduction of ADC were studied with serial MRI for up to 4 months after presentation. RESULTS: Ten of 72 screened patients who showed a lesion with a reduced ADC were each examined 4–7 times, resulting in 52 examinations in total. We identified a characteristic sequence of signal-intensity changes: 1) days 0–7: slight T2 hyperintensity and prominent ADC reduction (maximum, −66%), faint or no enhancement on postcontrast T1-weighted images; 2) days 7–10: prominent T2 hyperintensity and contrast enhancement, ADC normalization/pseudonormalization; 3) up to 4 weeks: elevated ADC values, prominent enhancement on postcontrast images; 4) after 4 weeks: partial reversibility of T2 hyperintensity, ADC elevation, and resolution of contrast enhancement. CONCLUSIONS: In a subgroup of patients with MS presenting soon after new symptom onset, a transient reduction of the ADC delineated a short and very early phase of MS lesion evolution. Subsequent pseudonormalization of the ADC occurred along with signs of the development of vasogenic edema. Abbreviations CISclinically isolated syndromeEPecho-planarNAWMnormal-appearing white matterRRMSrelapsing-remitting MS ER -