RT Journal Article
SR Electronic
T1 Retinoblastoma: Value of Dynamic Contrast-Enhanced MR Imaging and Correlation with Tumor Angiogenesis
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A3119
A1 F. Rodjan
A1 P. de Graaf
A1 P. van der Valk
A1 A.C. Moll
A1 J.P.A. Kuijer
A1 D.L. Knol
A1 J.A. Castelijns
A1 P.J.W. Pouwels
YR 2012
UL http://www.ajnr.org/content/early/2012/05/24/ajnr.A3119.abstract
AB BACKGROUND AND PURPOSE: Noninvasive evaluation of retinoblastoma treatment response has become more important due to increased use of eye-sparing treatments. We evaluated the relation between DCE-MR imaging and histopathologic parameters to determine the value of DCE-MR imaging in assessing tumor angiogenesis and prognostic features. MATERIALS AND METHODS: Fifteen consecutive patients with retinoblastoma (mean age, 24 months; range, 2–70 months) undergoing enucleation as the primary treatment (15 eyes) were scanned at 1.5T by using dedicated surface coils. Pretreatment DCE-MR imaging of the most affected eye was evaluated by 2 observers by using curve-pattern analysis, with the first 5 minutes of each curve and the full time-series described as κ5min and κ17min, respectively. Assessed histopathologic and immunologic parameters included optic nerve invasion, choroid invasion, MVD, tumor necrosis, and expression of VEGF and Flt-1. RESULTS: The median value of κ5min was 1.28 (range, 0.87–2.07) and correlated positively with MVD (P = .008). The median value of κ17min was 1.33 (range, 0.35–3.08) and correlated negatively with tumor necrosis (P = .002). Other histopathologic and immunohistopathologic parameters did not correlate with DCE-MR imaging parameters. Interobserver agreement was 0.53 for κ5min and 0.91 for κ17min. CONCLUSIONS: In retinoblastoma, the early phase of the DCE time curve positively correlates with MVD, while the presence of late enhancement is correlated with necrosis. Thus, the potential for DCE-MR imaging to noninvasively assess tumor angiogenesis and necrosis in retinoblastoma is promising and warrants further investigation. Abbreviations DCEdynamic contrast-enhancedFlt-1VEGF receptor-1κ5mincurve-pattern analysis of the first DCE time-seriesκ17mincurve-pattern analysis for the full datasetkeprate-constantKtranstransfer constantMVDmicrovessel densityveextravascular extracellular space per unit volume of tissueVEGFvascular endothelial growth factor