@article {Borges, author = {A.R. Borges and P. Lopez-Larrubia and J.B. Marques and S.G. Cerdan}, title = {MR Imaging Features of High-Grade Gliomas in Murine Models: How They Compare with Human Disease, Reflect Tumor Biology, and Play a Role in Preclinical Trials}, year = {2011}, doi = {10.3174/ajnr.A2959}, publisher = {American Journal of Neuroradiology}, abstract = {SUMMARY: Murine models are the most commonly used and best investigated among the animal models of HGG. They constitute an important weapon in the development and testing of new anticancer drugs and have long been used in preclinical trials. Neuroimaging methods, particularly MR imaging, offer important advantages for the evaluation of treatment response: shorter and more reliable treatment end points and insight on tumor biology and physiology through the use of functional imaging DWI, PWI, BOLD, and MR spectroscopy. This functional information has been progressively consolidated as a surrogate marker of tumor biology and genetics and may play a pivotal role in the assessment of specifically targeted drugs, both in clinical and preclinical trials. The purpose of this Research Perspectives was to compile, summarize, and critically assess the available information on the neuroimaging features of different murine models of HGGs, and explain how these correlate with human disease and reflect tumor biology. Abbreviations AIFarterial input functionATPadenosine triphosphateBOLDblood oxygen level{\textemdash}dependentDCEdynamic contrast-enhancedDSCdynamic susceptibility contrastFLASHfast low-angle shotgadolinium-DTPAgadolinium-diethylene-triamine pentaacetic acidGEMMgenetically engineered mouse modelGREgradient recalled-echoHGGhigh-grade gliomaMMP2matrix metalloproteinase type 2MVDmean vascular densityrCBVrelative cerebral blood volumeVEGFvascular endothelial growth factor}, issn = {0195-6108}, URL = {https://www.ajnr.org/content/early/2011/12/22/ajnr.A2959}, eprint = {https://www.ajnr.org/content/early/2011/12/22/ajnr.A2959.full.pdf}, journal = {American Journal of Neuroradiology} }