TY - JOUR T1 - Pulse-Triggered DTI Sequence with Reduced FOV and Coronal Acquisition at 3T for the Assessment of the Cervical Spinal Cord in Patients with Myelitis JF - American Journal of Neuroradiology JO - Am. J. Neuroradiol. DO - 10.3174/ajnr.A3254 AU - J. Hodel AU - P. Besson AU - O. Outteryck AU - H. Zéphir AU - D. Ducreux AU - A. Monnet AU - D. Chéchin AU - M. Zins AU - M. Rodallec AU - J.P. Pruvo AU - P. Vermersch AU - X. Leclerc Y1 - 2012/08/23 UR - http://www.ajnr.org/content/early/2012/08/23/ajnr.A3254.abstract N2 - BACKGROUND AND PURPOSE: DTI is a promising technique for imaging of the spinal cord, but the technique has susceptibility-induced artifacts. We evaluated a pulse-triggered DTI sequence with an rFOV technique and coronal acquisition for the assessment of the cervical spinal cord in patients with myelitis at 3T. MATERIALS AND METHODS: A rFOV acquisition was established by a noncoplanar application of the excitation and the refocusing pulse in conjunction with outer volume suppression. The DTI sequence was performed in the coronal plane in 12 healthy volunteers and 40 consecutive patients with myelitis. Probabilistic tractography of the posterior and lateral funiculi was performed from the C1 to C7 levels. FA, MD, aD, rD, and ratios of aD and rD were measured. RESULTS: In healthy volunteers, mean DTI indices within the whole-fiber pathways were the following: FA = 0.61, MD = 1.17 × 10−3 mm2/s, aD = 1.96 × 10−3 mm2/s, rD = 0.77 × 10−3 mm2/s, and ratios of aD and rD = 2.5. Comparison of healthy controls and patients with myelitis identified statistically significant differences for all DTI parameters. Different patterns of myelitis, including spinal cord atrophy and active inflammatory lesions, were recognized. There was a significant correlation between clinical severity and DTI parameters. CONCLUSIONS: The present work introduces a new approach for DTI of the cervical spinal cord at 3T, enabling a quantitative follow-up of patients with myelitis. Abbreviations aDaxial diffusivityFAfractional anisotropyHChealthy controlsMDmean diffusivityrDradial diffusivityrFOVreduced FOV ER -