RT Journal Article SR Electronic T1 New Applications of Nanotechnology for Neuroimaging JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology DO 10.3174/ajnr.A3543 A1 G. Suffredini A1 J.E. East A1 L.M. Levy YR 2013 UL http://www.ajnr.org/content/early/2013/03/28/ajnr.A3543.abstract AB SUMMARY: Advances in nanotechnology have the potential to dramatically enhance the detection of neurologic diseases with targeted contrast agents and to facilitate the delivery of focused therapies to the central nervous system. We present the physicochemical rationale for their use, applications in animal models, and ongoing clinical trials using these approaches. We highlight advances in the use of nanoparticles applied to brain tumor imaging, tumor angiogenesis, neurodegeneration, grafted stem cells, and neuroprogenitor cells. Abbreviations amyloid betaAβNOnitric oxideNOSnitric oxide synthasePBCApoly(n-butyl cyanoacrylate)QDotsquantum dotsSPIOsuperparamagnetic iron oxide